SNARE-mediated ACh release inhibitor
- Cleaves presynaptic SNARE proteins → acetylcholine vesicles cannot fuse and release
- Botulinum
- Local chemodenervation for dystonia, spasticity and cosmesis
- Effect lasts about three months
- Distant spread can impair swallowing/breathing
Drugs with this mechanism (1)
- Botulinum toxin — Blocks acetylcholine release; therapeutic for spasticity and cosmetic wrinkles.
Self-check
- How long does botulinum’s local effect last here?
About three months. - What can distant spread impair?
Swallowing and breathing.
All mechanisms · Open SNARE-mediated ACh release inhibitor in the interactive console ↗