Silver ion antimicrobial
- Silver ions bind bacterial cell walls, proteins and DNA
- Broad topical antimicrobial → ↓ burn-wound infection
- Argyria (gray skin) with prolonged systemic exposure
- Can cause leukopenia
Drugs with this mechanism (1)
- Silver sulfadiazine — Topical burn antimicrobial releasing silver ions.
Self-check
- What skin change can prolonged systemic silver exposure cause?
Argyria: gray skin. - Which white-cell abnormality can occur?
Leukopenia.
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