Pyridoxine sequestrant
- Functional vitamin B6 deficiency
- Binds pyridoxine
- Peripheral neuropathy and seizure risk
- Prophylactic pyridoxine prevents it
Drugs with this mechanism (3)
- Cycloserine — Second-line tuberculosis antibiotic; NMDA activity drives severe neuropsychiatric toxicity.
- Hydralazine — Direct arteriolar vasodilator; reflex tachycardia, drug-induced lupus.
- Isoniazid — First-line tuberculosis drug; hepatotoxicity and pyridoxine-responsive neuropathy shape use.
Self-check
- Which acute CNS risk accompanies functional B6 deficiency?
Seizures. - What prophylaxis prevents these B6-depletion effects?
Pyridoxine.
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