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Potassium binder

• Binds potassium in the gut for hyperkalemia
• Older resins cause constipation and colonic necrosis

Drugs with this mechanism (3)

• Patiromer — Nonabsorbed potassium binder that helps preserve RAAS therapy; too slow for emergencies.
• Sodium zirconium cyclosilicate — Rapid, nonabsorbed potassium binder; its sodium load can worsen edema.
• Sodium polystyrene sulfonate — Old sodium-exchange resin for hyperkalemia; slow, unreliable and linked to colonic necrosis with sorbitol.

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