Potassium binder
Potassium sequestrant
- ↑ fecal potassium elimination
- Treats hyperkalemia
- Acts in the lumen
- Older resins cause constipation and colonic necrosis
Drugs with this mechanism (3)
- Patiromer — Nonabsorbed potassium binder that helps preserve RAAS therapy; too slow for emergencies.
- Sodium zirconium cyclosilicate — Rapid, nonabsorbed potassium binder; its sodium load can worsen edema.
- Sodium polystyrene sulfonate — Old sodium-exchange resin for hyperkalemia; slow, unreliable and linked to colonic necrosis with sorbitol.
Self-check
- Through which route does potassium elimination increase?
Feces. - Which severe bowel injury is associated with older resins?
Colonic necrosis.
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