Glutathione depletion
- Chloroacetaldehyde, an ifosfamide metabolite, depletes glutathione in CNS and renal tubules
- Drives ifosfamide neurotoxicity (encephalopathy) and nephrotoxicity
- Distinct from the hepatic NAPQI/acetaminophen glutathione mechanism
Drugs with this mechanism (1)
- Chloroacet aldehyde — Toxic ifosfamide metabolite implicated in encephalopathy and kidney injury; distinct from bladder-toxic acrolein.
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