Glutathione depletion (CNS and renal)
- Depletes glutathione in CNS and renal tubules
- Neurotoxicity (encephalopathy) and nephrotoxicity
Drugs with this mechanism (1)
- Chloroacetaldehyde — Toxic ifosfamide metabolite implicated in encephalopathy and kidney injury; distinct from bladder-toxic acrolein.
Self-check
- What CNS toxicity follows this glutathione depletion?
Encephalopathy. - Which listed drug depletes glutathione in CNS and renal tubules?
Ifosfamide.
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