30S inhibitor (tetracycline)
Bacterial 30S ribosomal inhibitor — tetracycline (A-site block, bacteriostatic)
- Blocks aminoacyl-tRNA from the A site → bacteriostatic
- Chelates divalent cations — deposits in growing bone and teeth; bound by antacids, iron and dairy
- Photosensitivity; doxycycline is non-renal, minocycline vestibular and pigmenting
- Blocks aminoacyl-tRNA from the A site → bacteriostatic
- Chelates divalent cations — deposits in growing bone and teeth; bound by antacids, iron and dairy
- Photosensitivity; doxycycline is non-renal, minocycline vestibular and pigmenting
Drugs with this mechanism (3)
- Doxycycline — Versatile tetracycline for atypicals, tick-borne illness, and acne.
- Minocycline — Lipophilic tetracycline for acne and MRSA; dizziness and pigmentation.
- Tetracycline — Prototype of its antibiotic class; broad but limited by resistance and food chelation.
All mechanisms · Open 30S inhibitor (tetracycline) in the interactive console ↗