30S inhibitor (aminoglycoside)
Bacterial 30S ribosomal inhibitor — aminoglycoside (misreading, bactericidal)
- Binds 16S rRNA → misreading and faulty proteins; bactericidal, concentration-dependent, with a post-antibiotic effect
- Oxygen-dependent uptake → no anaerobe activity; synergy with cell-wall agents
- Nephrotoxicity and irreversible ototoxicity; neuromuscular blockade at high levels
- Binds 16S rRNA → misreading and faulty proteins; bactericidal, concentration-dependent, with a post-antibiotic effect
- Oxygen-dependent uptake → no anaerobe activity; synergy with cell-wall agents
- Nephrotoxicity and irreversible ototoxicity; neuromuscular blockade at high levels
Drugs with this mechanism (4)
- Amikacin — Aminoglycoside reserved for resistant Gram-negative and mycobacterial infection.
- Gentamicin — Aminoglycoside for serious Gram-negative infections; nephro- and ototoxic.
- Neomycin — Aminoglycoside too toxic for systemic use; oral for gut decontamination, topical otherwise.
- Tobramycin — Aminoglycoside favored for Pseudomonas, including inhaled use in cystic fibrosis.
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