Serine hydroxymethyltransferase cofactor
- Transfers one-carbon units in folate metabolism
- Required cofactor for serine hydroxymethyltransferase
- Links vitamin B6 to nucleotide synthesis
Drugs with this mechanism (1)
- Pyridoxal-5'-phosphate — The active B6 cofactor itself, for pyridoxine-unresponsive PLP-dependent epilepsy.
Self-check
- What is transferred in this folate-metabolism reaction?
One-carbon units. - Which biosynthetic process is linked to B6 through this reaction?
Nucleotide synthesis.
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