Histidine decarboxylase cofactor
- Synthesizes histamine
- Required cofactor for histidine decarboxylase
- One of many PLP-dependent decarboxylations
Drugs with this mechanism (1)
- Pyridoxal-5'-phosphate — The active B6 cofactor itself, for pyridoxine-unresponsive PLP-dependent epilepsy.
Self-check
- Which transmitter is synthesized by this B6-dependent pathway?
Histamine. - Which listed vitamin supplies the histidine-decarboxylase cofactor?
Vitamin B6 (pyridoxine).
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