Glutamate decarboxylase cofactor
- Synthesizes GABA from glutamate
- Required cofactor for glutamate decarboxylase
- B6 deficiency lowers GABA → seizures
Drugs with this mechanism (1)
- Pyridoxal-5'-phosphate — The active B6 cofactor itself, for pyridoxine-unresponsive PLP-dependent epilepsy.
Self-check
- Which transmitter is synthesized from glutamate here?
GABA. - Why can B6 deficiency cause seizures?
It lowers GABA.
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