Aromatic L-amino acid decarboxylase cofactor
- Makes dopamine and serotonin from their amino-acid precursors
- Required cofactor for aromatic L-amino acid decarboxylase
Drugs with this mechanism (1)
- Pyridoxal-5'-phosphate — The active B6 cofactor itself, for pyridoxine-unresponsive PLP-dependent epilepsy.
Self-check
- Which two transmitters are made from amino-acid precursors through this pathway?
Dopamine and serotonin. - Which listed vitamin supplies this decarboxylase cofactor?
Vitamin B6 (pyridoxine).
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