Progesterone receptor antagonist
- Blocks progesterone support of the endometrium and pregnancy
- Decidual breakdown and uterine sensitization
- Terminates pregnancy
- Also used in Cushing syndrome
Drugs with this mechanism (1)
- Mifepristone — Progesterone/glucocorticoid antagonist; medical abortion and Cushing-syndrome hyperglycemia.
Self-check
- What tissue breakdown follows progesterone-receptor antagonism?
Decidual breakdown. - Which listed drug antagonizes progesterone receptors?
Mifepristone.
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