PLP cofactor
Pyridoxal phosphate cofactor
- The active vitamin B6 cofactor
- Required for amino-acid decarboxylation/transamination and neurotransmitter synthesis
- The form given for isoniazid overdose seizures when the kinase step is blocked
Drugs with this mechanism (1)
- Pyridoxal-5'-phosphate — The active B6 cofactor itself, for pyridoxine-unresponsive PLP-dependent epilepsy.
Self-check
- Which amino-acid reactions require PLP?
Decarboxylation and transamination. - PLP is the active cofactor of which vitamin?
Vitamin B6.
All mechanisms · Open PLP cofactor in the interactive console ↗