NMDA receptor NAM
NMDA receptor negative allosteric modulator
- ↓ NMDA current without plugging the channel
- spermidine – ↑ autophagy, mitochondrial support, DNA/RNA stabilization ◇ supplements are used for longevity signaling
- spermine – strongest; major contributor to semen odor
- cadaverine – similar; produced during tissue decomposition
Drugs with this mechanism (1)
- Zinc — Essential trace mineral and NMDA modulator; OTC, used for colds and Wilson disease.
Self-check
- Does allosteric NMDA inhibition plug the channel?
No; it reduces current without plugging it. - Which listed polyamine is produced during tissue decomposition?
Cadaverine.
All mechanisms · Open NMDA receptor NAM in the interactive console ↗