NK3 antagonist
Neurokinin-3 receptor antagonist
- ↓ hypothalamic KNDy-neuron signaling
- Restabilizes the thermoregulatory center → ↓ menopausal hot flashes
- A non-hormonal vasomotor treatment
- Hepatotoxicity
Drugs with this mechanism (2)
- Elinzanetant — Dual NK1/NK3 (neurokinin) antagonist; hormone-free relief for menopausal hot flashes.
- Fezolinetant — Oral NK3 antagonist for menopausal hot flashes; avoids estrogen exposure.
Self-check
- How does NK3 blockade reduce menopausal hot flashes?
Restabilizes the thermoregulatory center. - Is NK3 blockade a hormonal vasomotor treatment?
No; it is non-hormonal.
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