Mucosal barrier
Ulcer-adherent mucosal barrier
- Shields ulcers from acid and pepsin
- Nonselective binding can trap other luminal drugs — separate dosing
Drugs with this mechanism (2)
- Bismuth subsalicylate — OTC mucosal protectant and antidiarrheal; salicylate toxicity and interactions still apply.
- Sucralfate — Sucrose-aluminum complex that polymerizes on ulcer craters; binds other drugs.
Self-check
- What do mucosal-barrier agents shield ulcers from?
Acid and pepsin. - Why separate other luminal drugs from a mucosal-barrier agent?
Nonselective binding can trap them.
All mechanisms · Open Mucosal barrier in the interactive console ↗