Bismuth subsalicylate
PEPTO-BISMOL
What it isBismuth–salicylate mucosal protectant with antisecretory and antibacterial effects; dyspepsia and acute diarrhea.
Why this oneUnlike simple antidiarrheals, it also belongs in bismuth quadruple therapy for Helicobacter pylori.
What limits itAvoid in children with viral illness and with other salicylates or anticoagulants; black tongue and stool are harmless.
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Diarrhea (OTC; per Directions) | Adults & children ≥12 y | 2 chewable tablets q30–60 min PRN | 2 tablets q30–60 min PRN | 8 doses (16 tablets)/24 h |
Renal Undefined
Hepatic Undefined
Do not exceed 8 doses (16 tablets) in 24 h; max 2 days of use
Instructions
- Chew completely or dissolve tablets in mouth
- Use until diarrhea stops but not more than 2 days
- Drink plenty of clear fluids to help prevent dehydration
- Children <12 y: ask a doctor
Pregnancy Undefined
Lactation Undefined
NO BOXED WARNINGS
Principal riskNo FDA boxed warning.
Classes and tags
Clinical profile
Mechanism of action: Bismuth subsalicylate ballicule
