Methionine synthase cofactor
- The cytoplasmic arm of vitamin B12
- Remethylates homocysteine to methionine, regenerating folate
- Required cofactor for methionine synthase
- The step that links B12 and folate deficiencies
Drugs with this mechanism (1)
- Methylcobalamin — Active vitamin B12; methionine-synthase cofactor.
Self-check
- Which reaction does methylcobalamin support?
Homocysteine remethylation to methionine. - Which enzyme requires methylcobalamin as a cofactor?
Methionine synthase.
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