MC2R agonist
Melanocortin-2 (ACTH) receptor agonist
- ↑ adrenal cortisol synthesis
- ACTH receptor activation
- Diagnostic and therapeutic stimulation of adrenal steroid output
- Works only with an intact, responsive adrenal cortex
Drugs with this mechanism (1)
- Corticotropin — Repository ACTH gel for infantile spasms; works through the adrenal axis.
Self-check
- Which adrenal hormone increases with MC2R activation?
Cortisol. - What adrenal condition is required for MC2R agonism to work?
An intact, responsive adrenal cortex.
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