MC1R agonist
Melanocortin-1 receptor agonism (hyperpigmentation)
- Off-target melanocortin receptor on melanocytes → ↑ eumelanin: skin darkening and new or darkened nevi
- Focal hyperpigmentation can persist after stopping
- Off-target melanocortin receptor on melanocytes → ↑ eumelanin: skin darkening and new or darkened nevi
- Focal hyperpigmentation can persist after stopping
Drugs with this mechanism (3)
- α-MSH — POMC-derived peptide: pigment at MC1R, appetite and energy at MC3R/MC4R.
- Bremelanotide — On-demand melanocortin-4 agonist injection for premenopausal hypoactive sexual desire disorder.
- Setmelanotide — MC4R agonist for genetic obesity syndromes.
All mechanisms · Open MC1R agonist in the interactive console ↗