Lysosomal alkalinizer
- Impairs antigen processing and autophagy
- Dampens autoimmune activation in lupus and rheumatoid arthritis
- Cumulative retinal toxicity
Drugs with this mechanism (1)
- Hydroxychloroquine — Antimalarial/antirheumatic; retinopathy and QT risk with chronic use.
Self-check
- Which two cellular processes does lysosomal inhibition impair?
Antigen processing and autophagy. - What cumulative toxicity is described with lysosomal inhibition?
Retinal toxicity.
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