Kv1 blocker
Kv1 potassium channel blocker
- Prolongs the action potential
- ↑ calcium entry and acetylcholine release → improves neuromuscular transmission (LEMS)
- Excess CNS excitation lowers the seizure threshold
- May cause seizure in healthy individuals due to excessive neurotransmitter release Kv1
- Restores conduction in demyelinated axons → improved walking in MS
Drugs with this mechanism (2)
- Amifampridine — Potassium-channel blocker for Lambert-Eaton myasthenic syndrome.
- Dalfampridine — Potassium-channel blocker that improves walking in multiple sclerosis.
Self-check
- How does Kv1 blockade improve transmission in LEMS?
Increases calcium entry and acetylcholine release. - How does excess CNS excitation from Kv1 blockade affect seizure threshold?
Lowers it.
All mechanisms · Open Kv1 blocker in the interactive console ↗