KIT/PDGFRA inhibitor
KIT and PDGFRA kinase inhibitor
- Suppresses gastrointestinal stromal tumors
- Blocks KIT and PDGFRA kinases
- Active against resistance mutations
- A broad-spectrum switch-control inhibitor for later-line GIST
- Hair and skin depigmentation
Drugs with this mechanism (1)
- Ripretinib — KIT/PDGFRA switch-control inhibitor for heavily pretreated gastrointestinal stromal tumors; alopecia and hand-foot syndrome are common.
Self-check
- Which tumor type is suppressed by KIT/PDGFRA inhibition?
Gastrointestinal stromal tumors. - Which pigmentation effect is described with KIT/PDGFRA inhibition?
Hair and skin depigmentation.
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