Kainate agonist
Kainate glutamate receptor agonist
- Slower excitatory currents than AMPA
- Glutamate
- Modulates synaptic activity
- ↑ spinal pain signaling
- Overactivation → hippocampal excitotoxicity, seizures, amnesia
Drugs with this mechanism (3)
- Domoic acid — Kainate-receptor agonist shellfish toxin causing amnesic poisoning.
- Glutamate — Primary excitatory CNS neurotransmitter.
- Kainate — Glutamate agonist that names the kainate receptor; an excitotoxin.
Self-check
- How fast are kainate currents relative to AMPA currents?
Slower. - What can excessive kainate activation cause in the hippocampus?
Excitotoxicity, seizures and amnesia.
All mechanisms · Open Kainate agonist in the interactive console ↗