Inositol monophosphatase inhibitor
- Depletes inositol
- Proposed to dampen overactive phosphoinositide signaling — the classic inositol-depletion hypothesis
- Never firmly established as the therapeutic mechanism
Drugs with this mechanism (2)
- Lithium — Gold-standard mood stabilizer and anti-suicide agent; narrow therapeutic index.
- Lithium ER — Extended-release lithium mood stabilizer; smoother peaks do not lessen renal interaction risk.
Self-check
- What does IMPase inhibition deplete?
Inositol. - Is inositol depletion firmly established as the therapeutic mechanism?
No.
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