HIV protease inhibitor
- Blocks cleavage of viral polyprotein — non-infectious virions
- Potent CYP3A4 inhibition drives extensive drug interactions
- Metabolic effects: dyslipidemia, lipodystrophy
Drugs with this mechanism (7)
- Atazanavir — HIV protease inhibitor; causes benign indirect hyperbilirubinemia.
- Darunavir — HIV protease inhibitor with a high genetic barrier; boosted with ritonavir.
- Indinavir — Early HIV protease inhibitor; nephrolithiasis.
- Lopinavir — HIV protease inhibitor always co-formulated with ritonavir.
- Nelfinavir — Early HIV protease inhibitor.
- Ritonavir — HIV protease inhibitor used mainly as a potent CYP3A "booster".
- Saquinavir — The first HIV protease inhibitor.
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