Heme detoxification inhibitor
Plasmodial heme detoxification inhibitor
- Blocks the parasite’s conversion of toxic heme into inert hemozoin
- Free heme accumulates and kills the Plasmodium
Drugs with this mechanism (1)
- Mefloquine — Long-acting antimalarial with well-known neuropsychiatric effects.
Self-check
- What inert product can the parasite no longer make during heme-detoxification blockade?
Hemozoin. - What accumulates and kills Plasmodium during heme-detoxification blockade?
Free heme.
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