NS5B non-nucleoside inhibitor
HCV NS5B polymerase inhibitor — non-nucleoside (palm site)
- Binds an allosteric palm pocket and locks the polymerase in an inactive conformation
- Genotype 1 only, low barrier to resistance — always part of a combination
- Binds an allosteric palm pocket and locks the polymerase in an inactive conformation
- Genotype 1 only, low barrier to resistance — always part of a combination
Drugs with this mechanism (1)
- Dasabuvir — Hepatitis C NS5B polymerase inhibitor.
All mechanisms · Open NS5B non-nucleoside inhibitor in the interactive console ↗