NS5B nucleotide inhibitor
HCV NS5B polymerase inhibitor — nucleotide chain terminator
- A nucleotide prodrug the active site mistakes for UTP — incorporation stops the chain
- The active site is conserved across genotypes → pangenotypic, high barrier to resistance
- With amiodarone: symptomatic bradycardia
- A nucleotide prodrug the active site mistakes for UTP — incorporation stops the chain
- The active site is conserved across genotypes → pangenotypic, high barrier to resistance
- With amiodarone: symptomatic bradycardia
Drugs with this mechanism (2)
- Bemnifosbuvir — Investigational nucleotide antiviral targeting viral RNA polymerase; being developed with ruzasvir for hepatitis C.
- Sofosbuvir — Nucleotide NS5B polymerase inhibitor central to curative hepatitis C combinations; amiodarone coadministration can cause serious bradycardia.
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