HCN1 PAM (channel opener)
HCN1 positive allosteric modulator (channel opener)
- Increased Ih current dampens dendritic excitability
- Positive allosteric modulation opens the HCN1 channel
Drugs with this mechanism (2)
- Lamotrigine XR — Extended-release lamotrigine for seizures; slow titration reduces serious-rash risk.
- Lamotrigine — Well-tolerated mood stabilizer for bipolar depression; slow titration for rash risk.
Self-check
- How does HCN1 enhancement affect dendritic excitability?
Increased Ih dampens it. - How does positive allosteric modulation affect HCN1 channels?
Opens them.
All mechanisms · Open HCN1 PAM (channel opener) in the interactive console ↗