H2 agonist
H2 histamine receptor agonist
- Gastric acid secretion from parietal cells
- Mild positive chronotropy/inotropy at cardiac H2
- Vasodilation (incl. coronary)
- Bronchodilation
- ↓ Uterine tone
- ↑ Renin release
Drugs with this mechanism (1)
- Histamine — Endogenous amine mediating arousal, allergy, and gastric acid.
Self-check
- Which gastric cells secrete acid in response to H2 activation?
Parietal cells. - How does cardiac H2 activation affect rate and contractility?
Mild increases in both.
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