GSK-3beta inhibitor
Glycogen synthase kinase-3 beta inhibitor
- Alters neuroplasticity, circadian and metabolic signaling
- A leading candidate mood-stabilizer mechanism
- A proposed mechanism of lithium
Drugs with this mechanism (2)
- Lithium — Gold-standard mood stabilizer and anti-suicide agent; narrow therapeutic index.
- Lithium ER — Extended-release lithium mood stabilizer; smoother peaks do not lessen renal interaction risk.
Self-check
- GSK3β inhibition is a proposed mechanism of which mood stabilizer?
Lithium. - Name two signaling domains altered by GSK3β inhibition.
Neuroplasticity and circadian signaling.
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