Glycine receptor agonist
- Chloride influx
- ↓ neuronal firing in spinal cord and brainstem
- Major role in motor control and pain processing GlyR
- The spinal counterpart of GABA-mediated inhibition
Drugs with this mechanism (1)
- Glycine — Spinal inhibitory neurotransmitter and NMDA co-agonist; also used as urologic irrigation fluid.
Self-check
- Which ion influx mediates glycine-receptor inhibition of neurons?
Chloride. - Where does glycine-receptor activation principally reduce neuronal firing?
Spinal cord and brainstem.
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