FLT3 inhibitor

FLT3 tyrosine kinase inhibitor

Blocks the FLT3 receptor tyrosine kinase driving proliferation in FLT3-mutant AML
ITD and TKD mutations differ in which inhibitors retain activity
Class effect: QT prolongation — correct potassium and magnesium before and during

Drugs with this mechanism (1)

Quizartinib — FLT3 inhibitor used with chemotherapy for newly diagnosed FLT3-ITD-positive AML; substantial QT-prolongation risk requires monitoring.

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