EPO receptor agonist
- Stimulates red-cell production — treats anemia of renal failure and chemotherapy
- Pushing hemoglobin high → hypertension and thrombosis
Drugs with this mechanism (2)
- Darbepoetin alfa — Long-acting erythropoietin-receptor agonist; fewer injections than epoetin.
- Epoetin alfa — Recombinant EPO for renal and chemo anemia; do not chase a normal hemoglobin.
Self-check
- What vascular risks increase if EPO therapy pushes hemoglobin too high?
Hypertension and thrombosis. - Which two anemia settings are listed for EPO receptor agonism?
Renal failure and chemotherapy.
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