DHPS inhibitor

Dihydropteroate synthase inhibitor

Blocks bacterial folate synthesis — the sulfonamides
Rash, including Stevens-Johnson syndrome

Drugs with this mechanism (2)

Dapsone — Sulfone antibiotic for leprosy and dermatitis herpetiformis; check G6PD before use.
Sulfamethoxazole — Sulfonamide antibiotic, paired with trimethoprim as co-trimoxazole.

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