ACL inhibitor
ATP-citrate lyase inhibitor
- Acts upstream of HMG-CoA reductase in cholesterol synthesis
- ↓ LDL cholesterol
- Raises uric acid
Drugs with this mechanism (1)
- Bempedoic acid — Liver-activated ATP-citrate lyase inhibitor; an oral LDL-lowering option in statin intolerance.
Self-check
- Is ACL upstream or downstream of HMG-CoA reductase?
Upstream. - Which acid level can ACL inhibition raise?
Uric acid.
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