11β-hydroxylase inhibitor
11β-hydroxylase inhibitor (adrenal cortisol synthesis)
- Blocks the last step of cortisol synthesis → adrenal suppression
- Etomidate: a single induction dose suppresses cortisol for hours; infusions raised mortality in septic patients
- Metyrapone and osilodrostat block the same enzyme on purpose, in Cushing’s
- Blocks the last step of cortisol synthesis → adrenal suppression
- Etomidate: a single induction dose suppresses cortisol for hours; infusions raised mortality in septic patients
- Metyrapone and osilodrostat block the same enzyme on purpose, in Cushing’s
Drugs with this mechanism (1)
- Etomidate — IV anesthetic with cardiovascular stability; suppresses adrenal steroids.
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