ENaC blocker
Epithelial sodium channel blocker
- ↓ Na⁺ reabsorption in the collecting duct
- Potassium-sparing diuresis; hyperkalemia risk
- Also the mechanism treating lithium-induced nephrogenic diabetes insipidus
Drugs with this mechanism (3)
- Amiloride — ENaC-blocking potassium-sparing diuretic; treats Liddle syndrome and lithium-induced diabetes insipidus.
- Triamterene — Potassium-sparing diuretic (ENaC blocker), often with hydrochlorothiazide.
- Trimethoprim — Antifolate antibiotic; paired with sulfamethoxazole, raises potassium/creatinine.
Self-check
- Where does ENaC inhibition reduce sodium reabsorption?
The collecting duct. - Which lithium-induced renal disorder can ENaC inhibition treat?
Nephrogenic diabetes insipidus.
All mechanisms · Open ENaC blocker in the interactive console ↗