ENaC blocker

Epithelial sodium channel blocker

Potassium-sparing diuresis in the collecting duct
Hyperkalemia risk

Drugs with this mechanism (2)

Amiloride — ENaC-blocking potassium-sparing diuretic; treats Liddle syndrome and lithium-induced diabetes insipidus.
Triamterene — Potassium-sparing diuretic (ENaC blocker), often with hydrochlorothiazide.

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