Delta-opioid agonist
Delta-opioid receptor agonist
- Modulates pain and mood without typical mu-opioid reward
- Neuroplasticity signaling (preclinical)
- ↑ BDNF production
- Anti-inflammatory effects
- High activation can provoke seizures
Drugs with this mechanism (2)
- Beta-endorphin — Endogenous opioid peptide acting at mu and delta receptors.
- Enkephalin — Endogenous delta-preferring opioid peptides.
Self-check
- What can high delta-opioid receptor activation provoke?
Seizures. - Which neurotrophic signal rises in preclinical delta-opioid agonism?
BDNF.
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