CYP51 inhibitor

Lanosterol 14-alpha-demethylase (CYP51) inhibitor

Blocks fungal ergosterol synthesis — the azoles
Potent CYP3A4 inhibition drives major interactions
Hepatotoxicity and QT prolongation

Drugs with this mechanism (3)

Fluconazole — Azole antifungal with good CNS penetration; a CYP2C9/3A inhibitor.
Miconazole — Topical azole antifungal.
Posaconazole — Broad triazole antifungal for prophylaxis in immunocompromised patients.

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