Central COX inhibitor
Central cyclooxygenase inhibition (acetaminophen)
- Inhibits COX where peroxide tone is low — the brain — and is out-competed at inflamed, peroxide-rich peripheral sites
- Analgesia and antipyresis without the anti-inflammatory, antiplatelet or gastric effects of the NSAID cards
- The AM404 metabolite adds central TRPV1/cannabinoid signaling
- Inhibits COX where peroxide tone is low — the brain — and is out-competed at inflamed, peroxide-rich peripheral sites
- Analgesia and antipyresis without the anti-inflammatory, antiplatelet or gastric effects of the NSAID cards
- The AM404 metabolite adds central TRPV1/cannabinoid signaling
Drugs with this mechanism (1)
- Acetaminophen — OTC analgesic/antipyretic; hepatotoxic in overdose, minimal anti-inflammatory effect.
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