Coenzyme A: fatty-acid metabolism
- Coenzyme A thioesters activate fatty acids for synthesis and beta-oxidation
- Acyl-CoA hands off to carnitine for transport
- Drug acyl-CoA trapping drains this pool
Drugs with this mechanism (1)
- Coenzyme A — Pantothenate-derived carrier of acyl groups; central to fatty-acid metabolism and cellular energy production.
Self-check
- Which carrier receives the acyl group from acyl-CoA for transport?
Carnitine. - What drug-related process can drain the coenzyme A pool?
Drug acyl-CoA trapping.
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