Coenzyme A
from pantothenic acid
What it isUniversal acyl-group carrier, synthesized from pantothenic acid (vitamin B5).
Why it mattersAcetyl-CoA sits at the crossroads of carbohydrate, fat, and protein metabolism — nothing in intermediary metabolism moves without it.
What it changesValproyl-CoA sequestration is one proposed mechanism of valproate hepatotoxicity and hyperammonemia.
NO BOXED WARNINGS
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Clinical profile
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Self-check
- Which vitamin supplies coenzyme A synthesis?
Pantothenic acid, vitamin B5. - Which proposed valproate toxicity mechanism involves coenzyme A?
Valproyl-CoA sequestration.