ClC-2 activator
ClC-2 chloride channel activator
- Intestinal chloride and water secretion → softer stool
- Nausea is the signature side effect
- Diarrhea
Drugs with this mechanism (1)
- Lubiprostone — Chloride-channel activator for chronic constipation.
Self-check
- How does intestinal ClC-2 activation soften stool?
Increases chloride and water secretion. - What is the signature adverse effect of intestinal ClC-2 activation?
Nausea.
All mechanisms · Open ClC-2 activator in the interactive console ↗