CFTR potentiator
- Increases chloride transport through defective CFTR
- Effect depends on which CFTR defect is present
Drugs with this mechanism (2)
- Ivacaftor — The first CFTR potentiator; opens gating-mutation channels already at the surface.
- Lumacaftor — CFTR corrector paired with ivacaftor; a strong 3A4 inducer that undercuts its own partner.
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