CB2 agonist
CB2 cannabinoid receptor agonist
- Immune-cell CB2 → reduces inflammation
- CB2 does not mediate the cannabis high — that is CB1
Drugs with this mechanism (3)
- 2-Arachidonoylglycerol — Most abundant endocannabinoid; full CB1 agonist made on demand by postsynaptic neurons.
- JWH-018 — A synthetic cannabinoid ("Spice"); a full CB1 agonist, unlike THC.
- Nabilone — Synthetic CB1 agonist for chemotherapy nausea refractory to standard antiemetics.
Self-check
- What immune effect does CB2 activation produce?
Reduced inflammation. - Which cannabinoid receptor mediates the high rather than CB2?
CB1.
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