2-Arachidonoylglycerol
2-AG
What it is2-arachidonoylglycerol, the most abundant endogenous cannabinoid, a full CB1 and CB2 agonist.
Why this onePrincipal retrograde messenger dampening neurotransmitter release—the mechanism THC hijacks.
What limits itIt explains why blocking its breakdown with a MAGL inhibitor was pursued as a non-intoxicating way to raise cannabinoid tone.
NO BOXED WARNINGS
Principal riskEndogenous or dietary; no boxed warning applies
Classes and tags
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Self-check
- Which cannabinoid receptors does 2-AG fully activate?
CB1 and CB2. - Which enzyme was targeted to block 2-AG breakdown?
MAGL.