2-Arachidonoyl glycerol
2-AG
What it is2-arachidonoylglycerol, the most abundant endogenous cannabinoid, a full CB1 and CB2 agonist.
Why this oneIt is the principal retrograde messenger dampening neurotransmitter release, which is the mechanism THC hijacks.
What limits itIt explains why blocking its breakdown with a MAGL inhibitor was pursued as a non-intoxicating way to raise cannabinoid tone.
NO BOXED WARNINGS
Principal riskEndogenous or dietary; no boxed warning applies
Classes and tags
Clinical profile
Mechanism of action: 2-Arachidonoyl glycerol ballicule
