CB1 agonist
CB1 cannabinoid receptor agonist
- Euphoria, analgesia, appetite stimulation, antiemetic effect
- Short-term memory and motor impairment
- driving risk
- Anxiolytic at low dose, anxiogenic at high dose
- Psychosis risk, dose-dependent
- Schizophrenia risk (adolescents)
- Tachycardia
- Tolerance / dependence
- Red eyes via vasodilation
Drugs with this mechanism (3)
- 2-Arachidonoylglycerol — Most abundant endocannabinoid; full CB1 agonist made on demand by postsynaptic neurons.
- JWH-018 — A synthetic cannabinoid ("Spice"); a full CB1 agonist, unlike THC.
- Nabilone — Synthetic CB1 agonist for chemotherapy nausea refractory to standard antiemetics.
Self-check
- How does CB1 agonist dose affect anxiety?
Low doses can relieve it; high doses can provoke it. - Why can CB1 agonism cause red eyes?
Vasodilation.
All mechanisms · Open CB1 agonist in the interactive console ↗