Beta-3 agonist

Beta-3 adrenergic receptor agonist

Relaxation of detrusor muscle – treatment for overactive bladder
Appetite suppression
Adipose tissue beiging (improved metabolism)
Negligible CNS effects

Drugs with this mechanism (3)

Mirabegron — Beta-3 agonist for overactive bladder without antimuscarinic side effects.
Nebivolol — Beta-1 blocker with beta-3 agonism and nitric-oxide-mediated vasodilation.
Vibegron — Cleaner beta-3 agonist for overactive bladder; no CYP2D6 inhibition.

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