Beta-3 agonist
Beta-3 adrenergic receptor agonist
- Relaxes the bladder during filling → treats overactive bladder
- Alternative to antimuscarinics — no dry mouth or cognitive load
- Appetite suppression
- Adipose tissue beiging (improved metabolism)
Drugs with this mechanism (3)
- Mirabegron — Beta-3 agonist for overactive bladder without antimuscarinic side effects.
- Nebivolol — Beta-1 blocker with beta-3 agonism and nitric-oxide-mediated vasodilation.
- Vibegron — Cleaner beta-3 agonist for overactive bladder; no CYP2D6 inhibition.
Self-check
- At what bladder phase does beta-3 agonism promote relaxation?
Filling. - Which salivary adverse effect of antimuscarinics does beta-3 agonism avoid here?
Dry mouth.
All mechanisms · Open Beta-3 agonist in the interactive console ↗